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cytosine-1-beta-D-arabinofuranoside CAS:147-94-4
Cytosine-1-beta-D-arabinofuranoside, commonly known as ara-C or cytarabine, is a nucleoside analog of cytosine. It features an arabinofuranosyl sugar, which enhances its stability and bioactivity in biological systems. Ara-C is primarily used in the treatment of various malignancies, particularly hematological cancers such as acute myeloid leukemia (AML) and non-Hodgkin lymphoma. Its mechanism of action involves incorporation into DNA, which leads to the inhibition of DNA synthesis and ultimately induces apoptosis in rapidly dividing cells. Due to its effectiveness against cancer, cytarabine remains a cornerstone in chemotherapy regimens.
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Cyclocytidine hydrochloride CAS:10212-25-6
Cyclocytidine hydrochloride is a cyclic nucleoside analog derived from cytidine, featuring a unique bicyclic structure that enhances its stability and bioactivity. It is primarily used in pharmaceutical research and development for its potential therapeutic applications, particularly in antiviral and anticancer treatments. Cyclocytidine can modulate nucleic acid metabolism and influence cellular mechanisms, making it a valuable compound for studying molecular interactions within cells. Its chemical properties enable researchers to explore novel pathways for drug design and delivery, offering promising avenues for the treatment of diseases associated with abnormal nucleic acid function.
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Adenosine Cyclophosphate CAS:60-92-4
Adenosine cyclophosphate, often referred to as cyclic adenosine monophosphate (cAMP), is a crucial second messenger in cellular signaling pathways. It is synthesized from ATP by the action of adenylate cyclase and plays an essential role in mediating various physiological responses in the body. cAMP functions by activating protein kinase A (PKA) and other signaling cascades, leading to diverse biological effects, including regulation of metabolism, gene expression, and cell proliferation. Its importance spans multiple systems, including the nervous and endocrine systems, making cAMP a key player in maintaining cellular homeostasis and responding to external stimuli.
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Adenosine 5′-monophosphate CAS:61-19-8
Adenosine 5′-monophosphate (AMP) is a nucleotide that plays a vital role in cellular metabolism and energy transfer. Composed of an adenine base, a ribose sugar, and a single phosphate group, AMP is involved in various biochemical processes, including the synthesis of adenosine triphosphate (ATP) and cyclic adenosine monophosphate (cAMP). As a signaling molecule, AMP regulates metabolic pathways and serves as an important precursor in nucleotide biosynthesis. Its levels within cells provide critical information about cellular energy status, making it essential for maintaining homeostasis and supporting physiological functions in living organisms.
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N(2),9-Diacetylguanine CAS:3056-33-5
N(2),9-Diacetylguanine is a synthetic derivative of guanine, notable for the addition of acetyl groups at the nitrogen positions 2 and 9. This modification alters the chemical properties and biological activities of guanine, enhancing its solubility and reactivity. N(2),9-Diacetylguanine serves as an important building block in nucleic acid chemistry, playing a significant role in research related to DNA and RNA structures. Its distinct characteristics make it valuable for developing novel probes and therapeutic agents, allowing scientists to investigate cellular mechanisms and gene regulation more effectively.
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Adenosine CAS:58-61-7
Adenosine is a nucleoside composed of adenine and ribose, playing a pivotal role in cellular metabolism. It serves as a fundamental building block for adenosine triphosphate (ATP), the primary energy currency in biological systems. Beyond its energy-related functions, adenosine is involved in various physiological processes, including neurotransmission, vasodilation, and regulation of the sleep-wake cycle. It acts on specific receptors, influencing heart rate and blood flow. Clinically, adenosine is utilized in medicine, particularly in the treatment of certain cardiac arrhythmias. Its multifaceted roles underscore the importance of adenosine in both health and disease.
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Uridine 5-monophosphate, disodium salt CAS:3387-36-8
Uridine 5-monophosphate, disodium salt (UMP) is a nucleotide that plays an essential role in cellular metabolism and RNA synthesis. Comprising the pyrimidine base uracil, a ribose sugar, and a phosphate group, UMP is vital for various biological processes, including the formation of nucleic acids and the regulation of metabolic pathways. The disodium salt form enhances its solubility and stability in aqueous solutions, making it suitable for both laboratory research and therapeutic applications. UMP has garnered attention for its potential neuroprotective and cognitive-enhancing properties, as well as its role in promoting overall cellular health.
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Cytidine 5′-(disodium phosphate) CAS:6757-06-8
Cytidine 5′-(disodium phosphate) is a nucleotide derivative composed of the pyrimidine base cytosine, the ribose sugar, and a phosphate group. This compound plays a critical role in various biochemical processes, including RNA synthesis, regulatory pathways, and cellular signaling. The disodium salt form enhances its solubility and stability in physiological conditions, making it suitable for laboratory research and potential therapeutic applications. Cytidine 5′-(disodium phosphate) has garnered interest for its involvement in nucleic acid metabolism and its potential benefits in enhancing cognitive function and supporting cellular health.
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5-Azacytidine CAS:320-67-2
5-Azacytidine is a synthetic nucleoside analogue of cytidine that contains a nitrogen atom in the 5-position of the pyrimidine ring, replacing a carbon atom. This modification imparts unique pharmacological properties, making it an essential compound in molecular biology and cancer therapy. As a potent DNA methyltransferase inhibitor, 5-azacytidine can reactivate silenced genes by altering DNA methylation patterns, thereby influencing gene expression. Originally developed for treating hematologic malignancies, 5-azacytidine has gained attention for its potential applications in epigenetic therapy, regenerative medicine, and research targeting various diseases characterized by abnormal gene regulation.
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2′-Fluoro-2′-deoxyuridine CAS:784-71-4
2′-Fluoro-2′-deoxyuridine (FdU) is a nucleoside analog of deoxyuridine, where the hydrogen atom at the 2′ position of the ribose sugar is replaced by a fluorine atom. This modification enhances the stability and bioactivity of the compound, making it valuable in biochemical research and therapeutic applications. FdU is particularly known for its role as an antiviral and anticancer agent, as it can interfere with DNA synthesis and inhibit the replication of certain viruses and cancer cells. Its unique properties make it a significant tool in the development of targeted therapies and molecular biology studies.
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![4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one CAS:10212-20-1](https://cdn.globalso.com/xindaobiotech/8NS8DBIRAVXN0VCLT260.png)
4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one CAS:10212-20-1
4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one is a complex nucleoside analog that features a pyrimidine base attached to a modified ribose sugar. The presence of a fluorine atom and hydroxyl groups in its structure enhances its biochemical properties, making it an interesting candidate for antiviral and anticancer research. This compound has potential applications in medicinal chemistry, particularly as a therapeutic agent targeting nucleic acid synthesis and metabolic pathways in pathogenic organisms. Its unique structural characteristics allow for better interaction with biological targets involved in DNA and RNA metabolism.
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1,3,5-tri-O-benzoyl-alpha-D-ribofuranose CAS:22224-41-5
1,3,5-Tri-O-benzoyl-alpha-D-ribofuranose is a chemically modified form of ribose, featuring three benzoyloxy groups attached to the 1, 3, and 5 positions of the ribofuranose structure. This modification enhances its solubility and stability, making it useful in various synthetic applications in organic chemistry and biochemistry. As a protected derivative of ribose, it serves as an intermediate in the synthesis of nucleosides and nucleotides, critical components of RNA and DNA. Its unique properties make 1,3,5-tri-O-benzoyl-alpha-D-ribofuranose valuable for researchers seeking to develop novel therapeutic agents and materials in nucleotide chemistry.
