methyl 5-(benzyloxymethyl)piperidine-2-carboxylate hydrochloride CAS:2891597-12-7

As a versatile building block, this molecule facilitates efficient pharmaceutical synthesis. N-dealkylations and additions to the piperidine nitrogen produce analog libraries for biological evaluation and structure-activity relationship exploration across therapeutic areas. Meanwhile, ester hydrolysis followed by derivatization furnishes targeted derivatives. These manipulations generate focused sets of compounds in a systematic manner. Additionally, the benzyl ether renders this suitable for metal-catalyzed cross-couplings to access heterocyclic fragments. The hydrochloride salt also ensures good solubility for reactions and screens. It can be further employed as a monomer for specialty polymer synthesis, imparting tailored properties. Therefore, with multiple reactive sites, this synthon supports versatile synthesis of drug-like molecules, polymer precursors and other specialized chemicals through diverse targeted transformations.