Copper Tripeptide-1 (GHK-Cu, CAS 89030-95-5) is a multifunctional bioactive peptide-copper complex with two primary domains of application, driven by its role as a cellular signaling molecule that promotes tissue repair and modulates gene expression.
Core Applications
1. Cosmetic & Skincare (Primary Market)
- Anti-Aging: Stimulates synthesis of collagen, elastin, and glycosaminoglycans (e.g., hyaluronic acid), reducing wrinkles and improving skin firmness and hydration.
- Antioxidant: Activates the endogenous antioxidant enzyme superoxide dismutase (SOD), protecting skin from oxidative stress.
- Repair & Healing: Accelerates wound healing, reduces scarring, and improves skin barrier function.
- Anti-Inflammatory: Calms skin, reduces redness, and soothes irritation.
- Hair Growth: Stimulates hair follicle cells, used in scalp treatments and hair loss serums.
2. Biomedical & Therapeutic
- Wound Healing: Enhances healing of chronic wounds (diabetic ulcers, burns) by attracting repair cells and modulating inflammation.
- Tissue Regeneration: Investigated for nerve repair, bone regeneration, and internal organ healing due to its ability to shift gene activity toward regenerative states.
- Post-Surgical Care: Used to minimize scarring and improve recovery.
Key Mechanisms
- Gene Modulation: Influences over 4,000 genes involved in tissue repair, inflammation, and antioxidant defense.
- Copper Delivery: Provides bioavailable copper as an essential cofactor for key enzymatic processes.
- Chemotaxis: Acts as a signal to recruit immune cells (macrophages) to sites of damage.
Typical Use in Formulations
- Concentration: 0.5% to 3% in serums, creams, gels, and masks.
- Synergies: Often combined with other peptides (e.g., Matrixyl), antioxidants (Vitamin C, E), and hyaluronic acid.
- Appearance: Characteristic blue color due to the copper complex.
- Stability: Requires protection from extreme pH, heat, and certain preservatives.
Safety & Notes
- Generally well-tolerated topically; rare irritation.
- Cosmetic-grade use is predominant; therapeutic wound-care applications are more regulated.
- Efficacy depends on formulation quality and skin penetration.
In summary, Copper Tripeptide is a versatile active ingredient whose dominant application is in high-performance anti-aging and repair skincare, with significant potential in advanced wound care and regenerative medicine.

Post time: Jan-02-2026
