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β-Nicotinamide Mononucleotide CAS:1094-61-7
Nicotinamide mononucleotide (NMN), a product of the NAMPT reaction and a key NAD+ intermediate, ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. NMN also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation. NMN is used for studying binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments.
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β-Nicotinamide Adenine Dinucleotide CAS:53-84-9
β-Nicotinamide adenine dinucleotide (NAD) is the oxidized form of β-Nicotinamide Adenine Dinucleotide. It exists as an anion under normal physio-logic conditions. It is functionally related to a deamido-NAD zwitterion. It is a conjugate base of a NAD(+). It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH).
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Ciclopirox Ethanolamine CAS:41621-49-2 Manufacturer Supplier
Ciclopirox ethanolamine is a broad spectrum antigfungal agent, it also exhibits antibacterial activity against many Gram-positive and Gram-negative bacteria, and has anti-inflammatory properties. It is used a a topical treatment of fungal skin an nail infections.
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Desvenlafaxine Succinate CAS:386750-22-7
Desvenlafaxine Succinate is a dual serotonin and norepinephrine reuptake inhibitor (SNRI) that was approved for the treatment of major depressive disorder (MDD) in the United States in 2008. In order to improve the efficacy and safety profile of venlafaxine, Wyeth discovered and developed one of the major metabolites of venlafaxine, namely the O-desmethyl metabolite (desvenlafaxine).
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Doxazosin Mesylate CAS:77883-43-3 Manufacturer Supplier
Doxazosin mesylate is a quinazoline compound that is a selective inhibitor of the alpha1 subtype of alpha adrenergic receptors. Doxazosin mesylate is a new generation of quinazolone α1 receptor blocker developed by the Pfizer company (United States), It has a long half-life, exerting its effects of dilating the blood vessels, reducing the vascular resistance and lowering the blood pressure through blocking the a 1 receptor. It has been recommended abroad as first-line clinical drugs of anti-hypertension and treatment of prostate disease.
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L-Isoleucine CAS:73-32-5 Manufacturer Supplier
L-Isoleucine, also known as Isoleucine, is an amino acid that is an isomer of leucine. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels.L-Isoleucine is an isomer of L-leucine and is an essential amino acid. It is synthesized from threonine and is a branched-chain hydrophobic amino acid.
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Captopril CAS:62571-86-2 Manufacturer Supplier
Captopril is the most studied of the angiotensin-converting enzyme inhibitors proposed as an antihypertensive drug. It blocks angiotensin-converting enzyme, which suppresses formation of angiotensin II and relieves its vasoconstricting effect on arterial and venous vessels. Overall vascular peripheral tension is reduced, which results in the lowering of arterial pressure.
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Candesartan CAS:139481-59-7 Manufacturer Supplier
Candesartan is an angiotensin II receptor I (AT1) antagonist, IC50s=1.12 and 2.86 nM for bovine adrenal cortex and rabbit aorta respectively.Selectively inhibits angiotensin II-induced contraction of rabbit aortic strips with no effect on contraction induced by other agents such as norepinephrine, KCl, serotonin, PGF2αor endothelin.
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Candesartana Cilexetila CAS:145040-37-5
Candesartan Celexetil is an ester analog of the angiotensin II antagonist Candesartan (sc-217825). Antagonism of this receptor prevents the binding of angiotensin II, a potent vasoconstrictor. This has the overall effect of vasodilation and an increased capillary blood volume. Candesartan Celexetil Ester is an inhibitor of AT1.
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Bupropion CAS:34911-55-2 Manufacturer Supplier
Bupropion is an aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring. It has a role as an antidepressant, an environmental contaminant and a xenobiotic. It is a secondary amino compound, a member of monochlorobenzenes and an aromatic ketone.
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Bezafibrate CAS:41859-67-0 Manufacturer Supplier
Bezafibrate is a monocarboxylic acid amide obtained by the formal condensation of the carboxy group of 4-chlorobenzoic acid with the amino group of 2-[4-(2-aminoethyl)phenoxy]-2-methylpropanoic acid. Benafibrate is used for the treatment of hyperlipidaemia. It has a role as a xenobiotic, an environmental contaminant, a geroprotector and an antilipemic drug. It is a monocarboxylic acid, an aromatic ether, a member of monochlorobenzenes and a monocarboxylic acid amide. It is functionally related to a propionic acid.
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Cetilistat CAS:282526-98-1 Manufacturer Supplier
Cetilistat is a new type of pancrelipase inhibitor for the treatment of obesity in diabetic and non-diabetic patients,A long-acting and potent specific gastrointestinal lipase inhibitor, which plays a therapeutic effect by forming a covalent bond with the active serine site of gastric lipase and pancreatic lipase in the stomach and small intestine to inactivate the enzyme. The enzymes of Living Chemicalbook cannot hydrolyze the fat in food, mainly triglycerides into absorbable free fatty acids and monoacylglycerols. Undigested triglycerides cannot be absorbed by the body, thereby reducing caloric intake and controlling weight.
